CROHNS-DISEASE AND ANASTOMOTIC RECURRENCE - MICROVASCULAR ISCHEMIA AND ANASTOMOTIC HEALING IN AN ANIMAL-MODEL

被引:35
作者
OSBORNE, MJ
HUDSON, M
PIASECKI, C
DHILLON, AP
LEWIS, AAM
POUNDER, RE
WAKEFIELD, AJ
机构
[1] UNIV LONDON,ROYAL FREE HOSP,INFLAMMATORY BOWEL DIS STUDY GRP,POND ST,LONDON NW3 2QG,ENGLAND
[2] UNIV LONDON,ROYAL FREE HOSP,DEPT SURG,LONDON NW3 2QG,ENGLAND
[3] UNIV LONDON,ROYAL FREE HOSP,DEPT MED,LONDON NW3 2QG,ENGLAND
[4] UNIV LONDON,ROYAL FREE HOSP,DEPT ANAT & HISTOPATHOL,LONDON NW3 2QG,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1002/bjs.1800800236
中图分类号
R61 [外科手术学];
学科分类号
摘要
Microvascular injury and ischaemia may be factors in anastomotic recurrence after resection for Crohn's disease. This hypothesis was explored in a ferret model of multifocal intestinal infarction. At laparotomy, isolated loops of small intestine were injected intraarterially with styrene microspheres (test loop) or saline (control). Al a second laparotomy 72 h later, test and control loops were divided and an end-to-end anastomosis performed between test loops (n = 2), test and control loops (n = 9) or control loops (n = 2). Abnormalities including chronic transmural inflammation, ulceration and granuloma formation were identified 2 weeks after the second operation in ten of the 11 surviving animals; changes were confined to the test loops and were most prominent adjacent to the anastomosis. No abnormalities were seen in control loops. The combination of two self-limiting ischaemic insults can produce a pattern of intestinal inflammation similar to that seen in anastomotic recurrence in Crohn's disease.
引用
收藏
页码:226 / 229
页数:4
相关论文
共 13 条
[1]  
Hadfield G, 1939, LANCET, V2, P773
[2]   A FERRET MODEL OF ACUTE MULTIFOCAL GASTROINTESTINAL INFARCTION [J].
HUDSON, M ;
PIASECKI, C ;
SANKEY, EA ;
SIM, R ;
WAKEFIELD, AJ ;
MORE, LJ ;
SAWYERR, AM ;
DHILLON, AP ;
POUNDER, RE .
GASTROENTEROLOGY, 1992, 102 (05) :1591-1596
[3]   CROHNS ILEITIS AND ILEOCOLITIS - A STUDY OF THE ANATOMICAL DISTRIBUTION OF RECURRENCE [J].
KOCH, TR ;
CAVE, DR ;
FORD, H ;
KIRSNER, JB .
DIGESTIVE DISEASES AND SCIENCES, 1981, 26 (06) :528-531
[4]  
MALCHOW H, 1990, 60 P FALK S, V28, P221
[5]   THE PULMONARY BIOPSY IN THE EARLY DIAGNOSIS OF WEGENERS (PATHERGIC) GRANULOMATOSIS - A STUDY BASED ON 35 OPEN LUNG BIOPSIES [J].
MARK, EJ ;
MATSUBARA, O ;
TANLIU, NS ;
FIENBERG, R .
HUMAN PATHOLOGY, 1988, 19 (09) :1065-1071
[6]   RELATION BETWEEN FLOW-PRESSURE-DIAMETER STUDIES IN EXPERIMENTAL STENOSIS OF RABBIT AND HUMAN SMALL-BOWEL [J].
MOREL, P ;
ALEXANDERWILLIAMS, J ;
ROHNER, A .
GUT, 1990, 31 (08) :875-878
[7]  
MORSON BC, 1972, CLIN GASTROENTEROL, P265
[8]   NATURAL-HISTORY OF RECURRENT CROHNS-DISEASE AT THE ILEOCOLONIC ANASTOMOSIS AFTER CURATIVE SURGERY [J].
RUTGEERTS, P ;
GEBOES, K ;
VANTRAPPEN, G ;
KERREMANS, R ;
COENEGRACHTS, JL ;
COREMANS, G .
GUT, 1984, 25 (06) :665-672
[9]   PREDICTABILITY OF THE POSTOPERATIVE COURSE OF CROHNS-DISEASE [J].
RUTGEERTS, P ;
GEBOES, K ;
VANTRAPPEN, G ;
BEYLS, J ;
KERREMANS, R ;
HIELE, M .
GASTROENTEROLOGY, 1990, 99 (04) :956-963
[10]   EFFECT OF FECAL STREAM DIVERSION ON RECURRENCE OF CROHNS-DISEASE IN THE NEOTERMINAL ILEUM [J].
RUTGEERTS, P ;
GOBOES, K ;
PEETERS, M ;
HIELE, M ;
PENNINCKX, F ;
AERTS, R ;
KERREMANS, R ;
VANTRAPPEN, G .
LANCET, 1991, 338 (8770) :771-774