ANTIGEN-ANTIBODY INTERACTIONS STUDY BY 2D-H-1 NMR - MOLECULAR RECOGNITION BETWEEN DECAPEPTIDE ANALOGS OF THE ACETYLCHOLINE-RECEPTOR ALPHA-67-76 FRAGMENT AND THE ANTI-ACHR ANTIBODIES

被引：5
作者：
CUNG, MT
MARRAUD, M
TSIKARIS, V
SAKARELLOS, C
PAPADOULI, I
TZARTOS, SJ
机构：
[1] UNIV IOANNINA,CHIM ORGAN & BIOCHIM LAB,GR-45110 IOANNINA,GREECE
[2] INST PASTEUR HELLEN,GR-11521 ATHENS,GREECE
来源：
JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1992年 / 89卷 / 02期
关键词：
D O I：
10.1051/jcp/1992890167
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To investigate the conformational role of the alpha-67-76 decapeptide fragment of the Torpedo acetylcholine receptor (AChR), each residue of the WNPADYGGIK sequence was substituted step by step by alanine. The 2D-NMR conformational study of the peptide analogues in the free state was carried out in DMSO. The COSY and transferred NOESY were applied to study the interactions of a monoclonal antibody (mAb6) directed against the main immunogenic region (MIR) of the AChR and five decapeptide analogues from the MIR.
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页码：167 / 173
页数：7
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