SIGNIFICANCE OF CHROMOSOMAL-ABNORMALITIES IN A MALIGNANT GIANT-CELL TUMOR OF BONE

被引：13
|
作者：
BRIDGE, JA
MOURON, BJ
NEFF, JR
BHATIA, PS
机构：
[1] UNIV KANSAS, MED CTR, DEPT PATHOL & ONCOL, KANSAS CITY, KS 66103 USA
[2] UNIV NEBRASKA, MED CTR, DEPT PEDIAT, OMAHA, NE 68198 USA
[3] UNIV NEBRASKA, MED CTR, DEPT ORTHOPAED SURG, OMAHA, NE 68198 USA
来源：
CANCER GENETICS AND CYTOGENETICS | 1991年 / 57卷 / 01期
关键词：
D O I：
10.1016/0165-4608(91)90193-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX,-1,-11,+22,del(2)(p22),t(7;7) (p22;q32),+ der(1)t(1;11;21)(p32;q13;q22),+ der(19)t(19;?)(q13.4;?),der(8)t(8;?)(p11;?), der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.
引用
收藏
页码：87 / 92
页数：6
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