SIGNIFICANCE OF CHROMOSOMAL-ABNORMALITIES IN A MALIGNANT GIANT-CELL TUMOR OF BONE

被引：13
作者：
BRIDGE, JA
MOURON, BJ
NEFF, JR
BHATIA, PS
机构：
[1] UNIV KANSAS, MED CTR, DEPT PATHOL & ONCOL, KANSAS CITY, KS 66103 USA
[2] UNIV NEBRASKA, MED CTR, DEPT PEDIAT, OMAHA, NE 68198 USA
[3] UNIV NEBRASKA, MED CTR, DEPT ORTHOPAED SURG, OMAHA, NE 68198 USA
来源：
CANCER GENETICS AND CYTOGENETICS | 1991年 / 57卷 / 01期
关键词：
D O I：
10.1016/0165-4608(91)90193-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX,-1,-11,+22,del(2)(p22),t(7;7) (p22;q32),+ der(1)t(1;11;21)(p32;q13;q22),+ der(19)t(19;?)(q13.4;?),der(8)t(8;?)(p11;?), der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.
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页码：87 / 92
页数：6
相关论文
共 32 条
[1]   GIANT-CELL TUMOR OF BONE - DETAILED FINE-STRUCTURAL ANALYSIS OF DIFFERENT CELL COMPONENTS [J].
APARISI, T ;
ARBORGH, B ;
ERICSSON, JLE .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1977, 376 (04) :273-298
[2]   AN IMMUNOHISTOLOGICAL STUDY OF GIANT-CELL TUMOR OF BONE - EVIDENCE FOR AN OSTEOCLAST ORIGIN OF THE GIANT-CELLS [J].
ATHANASOU, NA ;
BLISS, E ;
GATTER, KC ;
HERYET, A ;
WOODS, CG ;
MCGEE, JO .
JOURNAL OF PATHOLOGY, 1985, 147 (03) :153-158
[3]  
BRIDGE JA, 1990, CANCER, V65, P2697, DOI 10.1002/1097-0142(19900615)65:12<2697::AID-CNCR2820651217>3.0.CO
[4]  
2-3
[5]   MALIGNANT GIANT-CELL TUMOR OF BONE - ULTRASTRUCTURAL AND IMMUNOHISTOLOGIC EVIDENCE OF HISTIOCYTIC ORIGIN [J].
BROOKS, JP ;
PASCAL, RR .
HUMAN PATHOLOGY, 1984, 15 (11) :1098-1100
[6]   DELINEATION OF 4 CELL-TYPES COMPRISING THE GIANT-CELL TUMOR OF BONE - EXPRESSION OF IA AND MONOCYTE-MACROPHAGE LINEAGE ANTIGENS [J].
BURMESTER, GR ;
WINCHESTER, RJ ;
DIMITRIUBONA, A ;
KLEIN, M ;
STEINER, G ;
SISSONS, HA .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 71 (06) :1633-1648
[7]  
CAMPANACCI M, 1975, ITAL J ORTHOP TRAUMA, V1, P249
[8]  
DAHLIN DC, 1970, CANCER, V25, P1061, DOI 10.1002/1097-0142(197005)25:5<1061::AID-CNCR2820250509>3.0.CO
[9]  
2-E
[10]  
GOLDRING SR, 1986, CLIN ORTHOP RELAT R, P59
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