EVIDENCE FOR POLYMORPHONUCLEAR LEUKOCYTE COLLAGENASE AND 92-KILODALTON GELATINASE IN GINGIVAL CREVICULAR FLUID

被引：56
作者：
OVERALL, CM
SODEK, J
MCCULLOCH, CAG
BIREK, P
机构：
[1] UNIV TORONTO,MRC,PERIODONTOL PHYSIOL GRP,TORONTO M5S 1A1,ONTARIO,CANADA
[2] UNIV TORONTO,FAC DENT,TORONTO M5S 1A1,ONTARIO,CANADA
来源：
INFECTION AND IMMUNITY | 1991年 / 59卷 / 12期
关键词：
D O I：
10.1128/IAI.59.12.4687-4692.1991
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Analysis of inflammatory exudate collected from sites of experimental periodontitis in cynomolgus monkeys has revealed the presence of collagenase and a 92-kDa gelatinase that comigrated after electrophoresis with the 92-kDa gelatinase released from polymorphonuclear leukocytes. Since neutralizing antibodies to fibroblast collagenase had no effect on the collagenase activity and bacterial collagenases could not be detected, polymorphonuclear leukocytes appear to be the major source of collagenolytic proteinases in inflammatory fluid from gingiva.
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页码：4687 / 4692
页数：6
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