Scientific Opinion on the substantiation of a health claim related to increasing maternal folate status by supplemental folate intake and reduced risk of neural tube defects pursuant to Article 14 of Regulation (EC) No 1924/2006

被引：6

作者：

Agostoni, Carlo ^{[1
]}

Canani, Roberto Berni ^{[1
]}

Fairweather-Tait, Susan ^{[1
]}

Heinonen, Marina ^{[1
]}

Korhonen, Hannu ^{[1
]}

La Vieille, Sebastien ^{[1
]}

Marchelli, Rosangela ^{[1
]}

Martin, Ambroise ^{[1
]}

Naska, Androniki ^{[1
]}

Neuhaeuser-Berthold, Monika ^{[1
]}

Nowicka, Grazyna ^{[1
]}

Sanz, Yolanda ^{[1
]}

Siani, Alfonso ^{[1
]}

Sjoedin, Anders ^{[1
]}

Stern, Martin ^{[1
]}

Strain, Sean ^{[1
]}

Tetens, Inge ^{[1
]}

Tome, Daniel ^{[1
]}

Turck, Dominique ^{[1
]}

Verhagen, Hans ^{[1
]}

机构：

[1] EFSA, Parma, Italy

来源：

EFSA JOURNAL | 2013年 / 11卷 / 07期

关键词：

Folate; neural tube defects; NTD; health claims;

D O I：

10.2903/j.efsa.2013.3328

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Following an application from Rank Nutrition Ltd, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to increasing maternal folate status by supplemental folate intake and reduced risk of neural tube defects. The Panel considers that the food constituent, supplemental folate, which is the subject of the claim, is sufficiently characterised. Increasing maternal folate status by supplemental folate intake is a beneficial physiological effect in the context of reducing the risk of neural tube defects. In weighing the evidence, the Panel took into account that the association between low maternal folate intakes and an increased risk of neural tube defects is well established, and that a recent systematic review showed an effect of maternal folic acid intakes on the risk of neural tube defects. The Panel concludes that a cause and effect relationship has been established between increasing maternal folate status by supplemental folate intake and a reduced risk of neural tube defects. (C) European Food Safety Authority, 2013

引用

页数：9

共 16 条

[1] PREVENTION OF THE 1ST OCCURRENCE OF NEURAL-TUBE DEFECTS BY PERICONCEPTIONAL VITAMIN SUPPLEMENTATION [J].