Descriptive Consideration of Serum Irisin Levels Various Factors: Obesity, Type 2 Diabetes Mellitus, Pre-Diabetic Status, Gender, and Athletics

Aim: Recently obesity, has become the main risk for a number of conditions and metabolic syndrome including type 2 diabetes (T2DM). The aims of this study were to assess whether irisin can bring out the missing circle between increasing physical activity and weight reduction. Methods: 108 subjects were chosen to matched with 76 diabetic patients in age and BMI, both groups were divided into subgroups according to their BMI. 22 healthy athlete men were also involved in the study. Results: The mean (+/- SD) value of serum irisin concentrations of obese healthy individuals was the highest concentration (p= 0.015) in comparison with normal and overweight healthy individuals. The more recent observation which describe irisin as adipokine factor (willing myokine source), irisin levels were examine pursuant to gender, obese women group have had the highest level of serum irisin than other women studied groups (p= 0.001), while in healthy men serum irisin did not differ significantly. Carful examination were searched for irisin as a myokine after adjusting age and BMI for gender depending on that women had significantly lower serum irisin (p= 0.006) inspite of signficantly higher fat precentage (p= 0.001) when compared with men. signficantly lower serum irisin concentration in healthy men with normal physical activity (p= 0.01) than healthy athlete men pointed that irisin as myokine potentionally. Diabetic patients showed significant lower serum irisin level than healthy subjects. Conclusion: Serum irisin levels findings may reflect its protective role against developing insulin resistance.