NON-NMDA GLUTAMATERGIC EXCITATORY TRANSMISSION IN THE DESCENDING-LIMB OF THE SPINOBULBOSPINAL MICTURITION REFLEX PATHWAY OF THE RAT

被引：37

作者：

MATSUMOTO, G ^{[1
]}

HISAMITSU, T ^{[1
]}

DEGROAT, WC ^{[1
]}

机构：

[1] SHOWA UNIV,DEPT PHYSIOL,TOKYO,JAPAN

来源：

BRAIN RESEARCH | 1995年 / 693卷 / 1-2期

关键词：

AMPA/KAINATE RECEPTOR; GYKI-52466; CNQX; MICTURITION; PONTINE MICTURITION CENTER;

D O I：

10.1016/0006-8993(95)00738-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

I.v. administration of GYKI-52466, a non-competitive AMPA/kainate glutamatergic receptor antagonist, inhibited bladder contractions elicited by electrical stimulation in the pontine micturition center (PMC) in urethane-anesthetized rats. The mean threshold dose of GYKI-52466 was 2 mg/kg i.v. (range = 1-4 mg/kg). Maximum inhibition (mean = 57.7 +/- 8.2%, range = 24-83.3% of control) occurred at a dose of 8 mg/kg. CNQX, a competitive AMPA/kainate glutamatergic receptor antagonist, did not significantly alter the evoked contractions. These results indicate that AMPA/kainate receptors are involved in bulbospinal excitatory pathway from the PMC to the parasympathetic nucleus in the lumbosacral spinal cord in the rat.

引用

页码：246 / 250

页数：5