OPPOSING REGULATION OF AMYLOID PRECURSOR PROTEIN BY IONOTROPIC AND METABOTROPIC GLUTAMATE RECEPTORS

被引：16

作者：

VALERIO, A

ALBERICI, A

PATERLINI, M

GRILLI, M

GALLI, P

PIZZI, M

MEMO, M

SPANO, P

机构：

[1] Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, University of Brescia School of Medicine, Brescia, 25123

来源：

NEUROREPORT | 1995年 / 6卷 / 09期

关键词：

GLUTAMATE RECEPTORS; AMYLOID PRECURSOR PROTEIN; CEREBELLAR GRANULE CELLS;

D O I：

10.1097/00001756-199506090-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effects of the ionotropic glutamate receptor (iGluR) selective agonist N-methyl-D-aspartate (NMDA) on amyloid precursor protein (APP) levels were investigated in primary cultures of rat cerebellar granule cells. Both immunocytochemistry and immunoblotting techniques showed increased APP levels 4 h after a 15 min pulse with NMDA. This effect was completely prevented by incubating the neurones in the presence of the selective metabotropic GluR (mGluR) agonist 1S,3R-ACPD. This phenomenon was related, in terms of doses and time, with the observed 1S,3R-ACPD-mediated protection on NMDA-induced granule cell death. Our findings indicate that APP metabolism is differentially regulated by the stimulation of various GluR subtypes. The GluR-mediated changes in APP content might participate in the control of neuronal viability.

引用

页码：1317 / 1321

页数：5

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