FAS ANTIGEN MESSENGER-RNA INDUCTION IN POSTISCHEMIC MURINE BRAIN

被引：72

作者：

MATSUYAMA, T

HATA, R

TAGAYA, M

YAMAMOTO, Y

NAKAJIMA, T

FURUYAMA, J

WANAKA, A

SUGITA, M

机构：

[1] HYOGO MED UNIV,DEPT GENET,NISHINOMIYA,HYOGO 663,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT ANAT,SUITA,OSAKA 565,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 657卷 / 1-2期

关键词：

APOPTOSIS; FAS ANTIGEN; CEREBRAL ISCHEMIA; BALB/C MOUSE;

D O I：

10.1016/0006-8993(94)90989-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fas antigen mRNA induction in the brain was examined using a transient global cerebral ischemia model in BALB/C mice. Northern blot analysis revealed little Fas antigen mRNA expression in the brains of sham-operated mice. A marked induction of Fas mRNA expression was detected in the brains of mice 6 h after 30 min of cerebral ischemia. These results suggest a possible apoptotic mechanism for cell death, mediated by the Fas antigen, in postischemic brain.

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页码：342 / 346

页数：5

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