A HYDROPHILIC TETRAHYDRO-BETA-CARBOLINE IN HUMAN URINE

被引：30
|
作者：
HORIUCHI, K
YONEKAWA, O
IWAHARA, K
KANNO, T
KURIHARA, T
FUJISE, Y
机构：
[1] HAMAMATSU UNIV SCH MED, DEPT LAB MED, HAMAMATSU, SHIZUOKA 43131, JAPAN
[2] SAPPORO BREWERIES LTD, PHARMACEUT RES LABS, SHIZUOKA 425, JAPAN
来源：
JOURNAL OF BIOCHEMISTRY | 1994年 / 115卷 / 02期
关键词：
BETA-CARBOLINE; GABA-RECEPTOR; HUMAN URINE; TETRAHYDRO-BETA-CARBOLINE; WATER SOLUBLE;
D O I：
10.1093/oxfordjournals.jbchem.a124343
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A substance that exhibited a tryptophan-like fluorescence peak at 354 nm on excitation at 295 nm at neutral pH was isolated from human urine. This compound was determined by visible-light absorption spectroscopy, fluorescence spectroscopy, H-1 and C-13 NMR spectroscopies, and FAB-MS to be 1-(1',2',3',4',5' -pentahydroxypentyl)-1,2,3,4-tetrahydro-2-carboline-3-carboxylic acid. This compound, named tetrahydropentoxyline, is a new type of hydrophilic tetrahydro-beta-carboline, and its elution position was between those of 4-pyridoxic acid and kynurenic acid on C-18 reversed-phase HPLC. The amount of tetrahydropentoxyline excreted in the urine of normal subjects [n=21; age, 45 (SD 20) years] was about 5.2 (SD 1.0) mg per day.
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页码：362 / 366
页数：5
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