A HYDROPHILIC TETRAHYDRO-BETA-CARBOLINE IN HUMAN URINE

被引：30

作者：

HORIUCHI, K

YONEKAWA, O

IWAHARA, K

KANNO, T

KURIHARA, T

FUJISE, Y

机构：

[1] HAMAMATSU UNIV SCH MED, DEPT LAB MED, HAMAMATSU, SHIZUOKA 43131, JAPAN

[2] SAPPORO BREWERIES LTD, PHARMACEUT RES LABS, SHIZUOKA 425, JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1994年 / 115卷 / 02期

关键词：

BETA-CARBOLINE; GABA-RECEPTOR; HUMAN URINE; TETRAHYDRO-BETA-CARBOLINE; WATER SOLUBLE;

D O I：

10.1093/oxfordjournals.jbchem.a124343

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A substance that exhibited a tryptophan-like fluorescence peak at 354 nm on excitation at 295 nm at neutral pH was isolated from human urine. This compound was determined by visible-light absorption spectroscopy, fluorescence spectroscopy, H-1 and C-13 NMR spectroscopies, and FAB-MS to be 1-(1',2',3',4',5' -pentahydroxypentyl)-1,2,3,4-tetrahydro-2-carboline-3-carboxylic acid. This compound, named tetrahydropentoxyline, is a new type of hydrophilic tetrahydro-beta-carboline, and its elution position was between those of 4-pyridoxic acid and kynurenic acid on C-18 reversed-phase HPLC. The amount of tetrahydropentoxyline excreted in the urine of normal subjects [n=21; age, 45 (SD 20) years] was about 5.2 (SD 1.0) mg per day.

引用

页码：362 / 366

页数：5

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