LONG-RANGE CIS PREFERENCE IN DNA HOMOLOGY SEARCH OVER THE LENGTH OF A DROSOPHILA CHROMOSOME

被引：53
作者：
ENGELS, WR
PRESTON, CR
JOHNSONSCHLITZ, DM
机构：
[1] Genetics Department, University of Wisconsin, Madison
来源：
SCIENCE | 1994年 / 263卷 / 5153期
关键词：
D O I：
10.1126/science.8128250
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.
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页码：1623 / 1625
页数：3
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