ENANTIOSELECTIVE INHIBITION OF HUMAN-LEUKOCYTE ELASTASE

被引：10

作者：

GROUTAS, WC

BRUBAKER, MJ

VENKATARAMAN, R

STANGA, MA

机构：

[1] Department of Chemistry, Wichita State University, Wichita

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1992年 / 297卷 / 01期

关键词：

D O I：

10.1016/0003-9861(92)90652-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(RS)-Diethyl-2-benzylsuccinate was resolved using α-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methylsulfonyl)oxy] succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined. The k2 KI values for the R and S isomers were found to be 330 and 1500 m-1 s-1, respectively. © 1992.

引用

页码：144 / 146

页数：3

共 17 条

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