ASSIGNMENT OF THE HUMAN CYTOCHROME-P-450 NIFEDIPINE OXIDASE GENE (CYP3A4) TO CHROMOSOME-7 AT BAND Q22.1 BY FLUORESCENCE INSITU HYBRIDIZATION

被引：49

作者：

INOUE, K

INAZAWA, J

NAKAGAWA, H

SHIMADA, T

YAMAZAKI, H

GUENGERICH, FP

ABE, T

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT HYG,KYOTO 602,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT MED,KYOTO 602,JAPAN

[3] VANDERBILT UNIV,MED CTR,SCH MED,CTR MOLEC TOXICOL,NASHVILLE,TN 37232

[4] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

JAPANESE JOURNAL OF HUMAN GENETICS | 1992年 / 37卷 / 02期

关键词：

FLUORESCENCE INSITU HYBRIDIZATION; CYP3A4; CHROMOSOMAL MAPPING; CHROMOSOME-7;

D O I：

10.1007/BF01899734

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have used a full length cDNA clone (2.2 kb) for the human cytochrome P-450 nifedipine oxidase (CYP3A4) enzyme as a probe to determine its chromosome localization by fluorescence in situ hybridization. CYP3A4 was mapped on R-banded human prometaphase chromosomes, and the precise localization of CYP3A4 on chromosome 7 was further confirmed by a delineation of G-banded pattern on the same prometaphase chromosomes through a combination of UV-filter. We assigned CYP3A4 to chromosome 7 at q22.1.

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页码：133 / 138

页数：6

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