SYNAPTIC N-METHYL-D-ASPARTATE RECEPTORS IN THE NEONATAL RAT VISUAL-CORTEX ARE LESS SENSITIVE TO MK-801 THAN IN ADULT

被引：15
|
作者：
KATO, N
机构：
[1] Department of Integrative Brain Science, Faculty of Medicine, Kyoto University, Kyoto
来源：
BRAIN RESEARCH | 1993年 / 608卷 / 01期
关键词：
N-METHYL-D-ASPARTATE RECEPTOR; DEVELOPMENT; RAT; MK-801; SYNAPTIC POTENTIAL; GLUTAMATE RECEPTOR;
D O I：
10.1016/0006-8993(93)90790-T
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The excitatory postsynaptic potential mediated by N-methyl-D-aspartate (NMDA) receptors (NMDA-EPSP) was intracellularly obtained in slices from the visual cortex of adult and 2-week-old rats. Bath application of 0.3 muM (+)-MK-801, an NMDA receptor open-channel blocker, completely blocked NMDA-EPSPs in slices from adult rats. By contrast, in slices from the younger rats, a 10 muM solution was needed for the complete blockade. This difference in sensitivity to an open-channel blocker implies a major developmental change in the conformation of NMDA receptors in situ.
引用
收藏
页码：166 / 168
页数：3
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