CORONARY VASCULAR REACTIVITY IN THE SKATE, RAJA-NASUTA

被引：28

作者：

FARRELL, AP ^{[1
]}

DAVIE, PS ^{[1
]}

机构：

[1] PORTOBELLO MARINE LAB,OTAGO,NEW ZEALAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1991年 / 99卷 / 03期

关键词：

FISH HEART; RESPONSES;

D O I：

10.1016/0742-8413(91)90286-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Vasoactivity was examined in isolated vascular rings from the coronary arteries of the rough skate, Raja nasuta. 2. Adrenergic compounds produced contractions and relaxations, indicating a mixed population of alpha- and beta-adrenoceptors, respectively. 3. Adenosine contracted vascular rings. ADP and ATP contracted vascular rings at concentrations below 0.1 mM and relaxed them at higher concentrations. 4. Similarly, acetylcholine produced weak contractions at concentrations below 0.1 mM and strong relaxations at higher concentrations. Nitroglycerine also produced relaxations. 5. Nitroglycerine also produced relaxations. 6. The prostaglandin F2-alpha produced pronounced contractions. 7. Serotonin relaxed vascular rings. 8. Histamine, bradykinin and angiotensin II produced weak relaxations. 9. The responses of Raja nasuta are compared with the vascular reactivity previously reported for large coronary artery in rainbow trout, Salmo gairdneri, and mako shark, Isurus oxyrinchus.

引用

页码：555 / 560

页数：6

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