SURGICAL LATEX GLOVE ALLERGY - CHARACTERIZATION OF RUBBER PROTEIN ALLERGENS BY IMMUNOBLOTTING

被引：61

作者：

ALENIUS, H

TURJANMAA, K

PALOSUO, T

MAKINENKILJUNEN, S

REUNALA, T

机构：

[1] NATL PUBL HLTH INST, MANNERHEIMINTIE 166, SF-00300 HELSINKI, FINLAND

[2] UNIV HOSP HELSINKI, DEPT ALLERG DIS, HELSINKI, FINLAND

[3] UNIV JYVASKYLA, DEPT CELL BIOL, SF-40100 JYVASKYLA 10, FINLAND

[4] UNIV TAMPERE, DEPT DERMATOL, TAMPERE, FINLAND

[5] UNIV TAMPERE, DEPT CLIN SCI, TAMPERE, FINLAND

[6] UNIV HOSP HELSINKI, DEPT DERMATOL, HELSINKI, FINLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 96卷 / 04期

关键词：

D O I：

10.1159/000235525

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Immunoblot analysis employing IgE antibodies derived from sera of 3 physicians and 2 nurses allergic to surgical latex gloves, disclosed 10 allergens in natural rubber sap. Nine of the 10 allergens were detected in ammoniated natural rubber latex, but only 4 allergens in a latex glove extract. The allergenic proteins had apparent molecular weights ranging from 14 to 70 kD. Allergens with molecular weights of 14 and 21 kD showed the most intense immunoblot reactions suggesting that these proteins could be the major allergens in the natural rubber. An 11-kD protein and a 26-kD protein were only seen in the glove extract, indicating that they could be modified rubber proteins formed during glove manufacture.

引用

页码：376 / 380

页数：5

共 21 条

[1] CHARACTERIZATION OF ALLERGENIC COMPONENTS IN SAP EXTRACT FROM THE WEEPING FIG (FICUS-BENJAMINA) [J].