SELECTIVE DESILYLATION OF TERT-BUTYLDIMETHYLSILYL ETHERS OF PHENOLS USING POTASSIUM FLUORIDE-ALUMINA AND ULTRASOUND

被引：90

作者：

SCHMITTLING, EA ^{[1
]}

SAWYER, JS ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY RES LAB,LILLY CORP CTR,DIV PULM & CARDIOVASC RES,INDIANAPOLIS,IN 46285

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 49期

关键词：

D O I：

10.1016/0040-4039(91)80477-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of potassium fluoride on basic alumina in acetonitrile with ultrasound for the selective deprotection of tert-butyldimethysilyl ethers of phenols is described. The method, which features a non-aqueous work-up, readily cleaves tert-butyldimethylsilyl ethers of phenols at room temperature, whereas tert-butyldimethylsilyl ethers of benzyl alcohols or 2-(trimethylsilyl)ethoxymethyl ethers of phenols are stable.

引用

页码：7207 / 7210

页数：4

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