SELECTIVE DESILYLATION OF TERT-BUTYLDIMETHYLSILYL ETHERS OF PHENOLS USING POTASSIUM FLUORIDE-ALUMINA AND ULTRASOUND

被引：90
|
作者：
SCHMITTLING, EA [1 ]
SAWYER, JS [1 ]
机构：
[1] ELI LILLY & CO,LILLY RES LAB,LILLY CORP CTR,DIV PULM & CARDIOVASC RES,INDIANAPOLIS,IN 46285
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 49期
关键词：
D O I：
10.1016/0040-4039(91)80477-N
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The use of potassium fluoride on basic alumina in acetonitrile with ultrasound for the selective deprotection of tert-butyldimethysilyl ethers of phenols is described. The method, which features a non-aqueous work-up, readily cleaves tert-butyldimethylsilyl ethers of phenols at room temperature, whereas tert-butyldimethylsilyl ethers of benzyl alcohols or 2-(trimethylsilyl)ethoxymethyl ethers of phenols are stable.
引用
收藏
页码：7207 / 7210
页数：4
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