SYNTHESIS OF MEVALONOLACTONE-2,3-C-13(2)

被引：3

作者：

DEGRAW, JI

UEMURA, I

机构：

[1] Department of Bio-Organic Chemistry, Sri International, Menlo Park, California

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 04期

关键词：

!sup]13[!/sup]C‐NMR; Biosynthesis; Mevalonolactone‐2,3‐[!sup]13[!/sup]C[!sub]2[!/sub;

D O I：

10.1002/jlcr.2580160406

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of mevalonolactone with 13C‐labels at positions 2 and 3 is reported. Hydrolysis of methyl 3‐hydroxy‐3‐methyl‐5,5‐dimethoxy‐valerate‐2,3‐13C2 to the aldehydo acid followed by reduction with sodium borohydride yielded the title compound. The material is useful as a substrate in biosynthetic studies using 13C‐NMR as an analytical tool. Copyright © 1979 John Wiley & Sons, Ltd.

引用

页码：547 / 549

页数：3