CENTRAL NORADRENERGIC-CHOLINERGIC INTERACTION AND LOCOMOTOR BEHAVIOR

被引：21
作者：
MASON, ST [1 ]
机构：
[1] UNIV BRITISH COLUMBIA, DEPT PSYCHIAT, DIV NEUROL SCI, VANCOUVER V6T 1W5, BC, CANADA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 56卷 / 1-2期
关键词：
6-Hydroxydopamine; Anticholinergics; Catalepsy; Cholinergics; Locomotor activity; Locus coeruleus; Noradrenaline;
D O I：
10.1016/0014-2999(79)90442-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Depletion of forebrain noradrenaline (norepinephrine) by intracerebral injection of 4 .mu.g of 6-hydroxydopamine into the fibers of the dorsal noradrenergic bundle blocked the cataleptic effects of the muscarinic cholinergic agonist arecoline and to potentiate the locomotor stimulant effects of the muscarinic cholinergic blocker scopolamine. The nicotinic drugs, mecamylamine, a nicotinic blocker, and nicotine itself were unaffected in their actions by the depletion of forebrain noradrenaline. A noradrenergic-cholinergic interaction of the muscarinic type exists in rat brain and may have a function in the control of arousal, with catalepsy at 1 extreme and locomotor stimulation at the other.
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页码：131 / 137
页数：7
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