HUMAN URINARY INTESTINAL ALKALINE-PHOSPHATASE AS AN INDICATOR OF S3-SEGMENT-SPECIFIC ALTERATIONS IN INCIPIENT DIABETIC NEPHROPATHY

被引:0
作者
NUYTS, GD
YAQOOB, M
NOUWEN, EJ
PATRICK, AW
MCCLELLAND, P
MACFARLANE, IA
BELL, GM
DEBROE, ME
机构
[1] UNIV HOSP ANTWERP,DEPT NEPHROL HYPERTENS,WILRIJKSTR 10,B-2650 EDEGEN ANTWERP,BELGIUM
[2] ROYAL LIVERPOOL UNIV HOSP,LIVERPOOL,ENGLAND
[3] WALTON GEN HOSP,LIVERPOOL,ENGLAND
关键词
DIABETIC NEPHROPATHY; EARLY MARKERS; INTESTINAL ALKALINE PHOSPHATASE; S3; SEGMENT; URINARY ENZYMES;
D O I
暂无
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Urinary enzymes were determined in a controlled study including 28 type I diabetes mellitus patients. Fifteen patients had persistent microalbuminuria and were compared to 13 normoalbuminuric patients with comparable age and sex distribution. All patients had normal renal function as measured by serum creatinine. Human intestinal alkaline phosphatase (hIAP), a specific marker of the proximal tubular S3 segment, was elevated in the urine of microalbuminuric patients while human tissue non-specific alkaline phosphatase (hTNAP), indicating effects mainly at the S1-S2 segments, was not. Urinary hIAP was correlated with serum glycated haemoglobin. These results suggest that tubular alterations are present at an early stage of diabetic nephropathy, especially at the S3 segment, and that hIAP may have promise as an early marker.
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页码:377 / 381
页数:5
相关论文
共 19 条
  • [1] ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS AND PROGRESSION OF DIABETIC NEPHROPATHY
    BAKRIS, GL
    [J]. ANNALS OF INTERNAL MEDICINE, 1993, 118 (08) : 643 - 644
  • [2] DIABETIC NEPHROPATHY IN INSULIN-DEPENDENT PATIENTS
    BREYER, JA
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1992, 20 (06) : 533 - 547
  • [3] CARDENAS A, 1993, BRIT J IND MED, V50, P17
  • [4] DETERMINATION OF SERUM CREATININE BY A DIRECT COLORIMETRIC METHOD
    HEINEGAR.D
    TIDERSTR.G
    [J]. CLINICA CHIMICA ACTA, 1973, 43 (03) : 305 - 310
  • [5] KREISBERG JI, 1988, ACUTE RENAL FAILURE, P45
  • [6] PRECLINICAL DETECTION OF NEPHROTOXICITY - DESCRIPTION OF THE TESTS AND APPRAISAL OF THEIR HEALTH SIGNIFICANCE
    LAUWERYS, R
    BERNARD, A
    [J]. TOXICOLOGY LETTERS, 1989, 46 (1-3) : 13 - 29
  • [7] RAPID COLORIMETRIC ASSAY OF BETA-GALACTOSIDASE AND N-ACETYL-BETA-GLUCOSAMINIDASE IN HUMAN URINE
    MARUHN, D
    [J]. CLINICA CHIMICA ACTA, 1976, 73 (03) : 453 - 461
  • [8] MAUNSBACH AB, 1992, HDB PHYSL 8, V1, P41
  • [9] MICROALBUMINURIA AS A PREDICTOR OF CLINICAL DIABETIC NEPHROPATHY
    MOGENSEN, CE
    STEFFES, MW
    MYERS, BD
    VIBERTI, G
    FRIEDMAN, EA
    DECKERT, T
    MADIAS, NE
    ANDERSEN, OO
    MAUER, SM
    OSTERBY, R
    PARVING, HH
    [J]. KIDNEY INTERNATIONAL, 1987, 31 (02) : 673 - 689
  • [10] NEPHROPATHIES AND EXPOSURE TO PERCHLOROETHYLENE IN DRY-CLEANERS
    MUTTI, A
    ALINOVI, R
    BERGAMASCHI, E
    BIAGINI, C
    CAVAZZINI, S
    FRANCHINI, I
    LAUWERYS, RR
    BERNARD, AM
    ROELS, H
    GELPI, E
    ROSELLO, J
    RAMIS, I
    PRICE, RG
    TAYLOR, SA
    DEBROE, M
    NUYTS, GD
    STOLTE, H
    FELS, LM
    HERBORT, C
    [J]. LANCET, 1992, 340 (8813) : 189 - 193