CONFORMATIONAL-ANALYSIS AND RECEPTOR MODELING OF M1 AND M2 SELECTIVE ANTAGONISTS

被引：0
|
作者：
KERCKHOFF, H [1 ]
HOLTJE, HD [1 ]
机构：
[1] FREIEN UNIV,INST PHARM,D-14195 BERLIN,GERMANY
来源：
PHARMAZIE | 1994年 / 49卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
On the basis of an elaborate conformational analysis of m1- and m2-selective antagonists a respective pharmacophore was deduced. This then was introduced into models of the two muscarinic receptor subtypes. These models were constructued starting from bacteriorhodopsin as a template in accordance with alignment data and mutation experiments. The validity of the interaction geometries between ligands and receptor subtypes is supported by a significant correlation between calculated interaction energies and experimentally determined affinity data.
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页码：566 / 573
页数：8
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