AMPHOTERICIN-B DELAYS BOTH SCRAPIE AGENT REPLICATION AND PRP-RES ACCUMULATION EARLY IN INFECTION

被引：50

作者：

MCKENZIE, D

KACZKOWSKI, J

MARSH, R

AIKEN, J

机构：

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 11期

关键词：

D O I：

10.1128/JVI.68.11.7534-7536.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Amphotericin B delays the onset of clinical symptoms in hamsters infected with scrapie agent strain 263K. Here we show that accumulation of a scrapie-specific isoform of the prion protein (PrP-res) and agent replication were delayed early in amphotericin B-treated animals. By 8 weeks postinfection, only untreated animals exhibited clinical symptoms of scrapie infection whereas PrP-res levels and titers were similar in treated and untreated animals. This suggests that although PrP-res accumulation and agent replication are linked, they are not the sole factors required for the onset of clinical disease.

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页码：7534 / 7536

页数：3

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