A CONVENIENT AND NEW ONE-STEP SYNTHESIS OF 1H-IMIDAZOLE-2-CARBOXAMIDES

被引：1

作者：

SINGH, B

机构：

[1] Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Rensselaer

来源：

HETEROCYCLES | 1992年 / 34卷 / 12期

关键词：

D O I：

10.3987/COM-92-6169

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2-Diketone monophenylhydrazones (2) reacted with aminomalonamide in 1-methyl-2-pyrrolidinone to provide 1-H-imidazole-2-carboxamides (4). The condensation of 1-(4-pyridinyl)-2-propanone with phenyldiazonium chloride gave 1-phenylhydrazono-1-(4-pyridinyl)-2-propanone (2a). 4-Methyl-5-(4-pyridinyl)-1H-imidazole-2-carboxamide (4a) was converted to the corresponding nitrile (5a) by the action of phosphorous oxychloride.

引用

页码：2373 / 2378

页数：6

共 14 条

[1]

BRUMAGNIEZ N, 1990, Patent No. 385850

[2]

Cassidy P.E., 1980, THERMALLY STABLE POL

[3] POTENTIAL ANTITUMOR AGENTS .59. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 2-PHENYLBENZIMIDAZOLE-4-CARBOXAMIDES, A NEW CLASS OF MINIMAL DNA-INTERCALATING AGENTS WHICH MAY NOT ACT VIA TOPOISOMERASE-II [J].