EFFECT OF IGM-ENRICHED INTRAVENOUS IMMUNOGLOBULIN (PENTAGLOBIN) ON ENDOTOXEMIA AND ANTIENDOTOXIN ANTIBODIES IN BONE-MARROW TRANSPLANTATION

被引：47

作者：

JACKSON, SK ^{[1
]}

PARTON, J ^{[1
]}

BARNES, RA ^{[1
]}

POYNTON, CH ^{[1
]}

FEGAN, C ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT HAEMATOL,CARDIFF CF4 4XN,S GLAM,WALES

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 23卷 / 09期

关键词：

ANTIBODIES; BONE MARROW TRANSPLANT; ENDOTOXIN; IMMUNOGLOBULIN; INTRAVENOUS;

D O I：

10.1111/j.1365-2362.1993.tb00963.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endotoxin was measured in over 1000 plasma samples from bone marrow transplant patients in a randomized trial of the IgM-enriched intravenous immunoglobulin (IVIG) Pentaglobin. Peak endotoxaemia was significantly reduced (P=0.02) in patients receiving Pentaglobin and 70% of all pyrexias of unknown origin were associated with endotoxaemia. Gut mucosal damage, assessed by lactulose/mannitol ratios, was significantly associated (P=0.02) with endotoxaemia. Specific IgM antibody to endotoxin core-glycolipid was significantly raised (P<0.01) in patients receiving the IVIG, and the IgM fraction of Pentaglobin was found to contain most of the antiendotoxin antibody activity of the IVIG. These results, suggest a role for IgM-enriched IVIG as a prophylactic agent for the reduction of endotoxaemia and its consequences in bone marrow transplant patients.

引用

页码：540 / 545

页数：6

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