ALZHEIMERS-DISEASE AND AGING - A CHROMOSOMAL APPROACH

被引：0
作者：
KORMANNBORTOLOTTO, MH
SMITH, MDC
NETO, JT
机构：
[1] ESCOLA PAULISTA MED SCH, DEPT MORFOL, DISCIPLINA GENET, BR-04023 SAO PAULO, BRAZIL
[2] ESCOLA PAULISTA MED SCH, SETOR GERIATR & GERONTOL, BR-04023 SAO PAULO, BRAZIL
来源：
GERONTOLOGY | 1993年 / 39卷 / 01期
关键词：
ALZHEIMERS DISEASE; AGING; CHROMOSOMAL ABNORMALITIES; CYTOGENETICS;
D O I：
暂无
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Alzheimer's disease (AD) is the most common type of dementia in elderly people. Interrelations between AD and senescence have been the subject of many studies. Some researchers have suggested that chromosomal alterations may be involved in the etiology or pathogenesis of AD. We present cytogenetic findings in patients with Alzheimer's disease, normal elderly controls and young controls. Aneuploidy, premature centromere division, polyploidy and C-anaphase, were analysed and the results suggest that the cytogenetic alterations observed are inherent to the cellular ageing process and not specifically related to Alzheimer's disease.
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页码：1 / 6
页数：6
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