Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance

被引：0

作者：

Ross, Daniel W. ^{[1
]}

Wanchoo, Rimda ^{[1
]}

Guigova, Adriana ^{[2
]}

Ghiuzeli, Cristina ^{[2
]}

Allen, Steven L. ^{[2
]}

Jhaveri, Kenar D. ^{[1
]}

机构：

[1] Hofstra Northwell Sch Med, Dept Med, Div Kidney Dis & Hypertens, 450 Lakeville Rd, Lake Success, NY 11042 USA

[2] Hofstra Northwell Sch Med, Dept Med, Div Hematol, 450 Lakeville Rd, Lake Success, NY 11042 USA

来源：

CEN CASE REPORTS | 2016年 / 5卷 / 02期

关键词：

Acute myeloid leukemia; Light chain Fanconi syndrome; MGUS; Onconephrology; MGRS;

D O I：

10.1007/s13730-016-0232-3

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Proximal tubules are a target for paraproteinemic diseases. Cast nephropathy, light chain deposition diseases, and amyloidosis are frequently encountered in patients with multiple myeloma. Rarely, a subset of patients develop light chain Fanconi syndrome (LCFS). LCFS has been reported with multiple myeloma, monoclonal gammopathy of renal significance (MGRS), chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia and diffuse large B-cell lymphoma. No cases have been described with other hematologic malignancies. We report the first case of lambda LCFS in a patient with both acute myeloid leukemia (AML) and monoclonal gammopathy of undetermined significance (MGUS).

引用

页码：238 / 241

页数：4

共 11 条

[1]

Aruna R, 2010, INDIAN J MED PAEDIAT, V31, P36

[2] Proximal Tubulopathies Associated With Monoclonal Light Chains The Spectrum of Clinicopathologic Manifestations and Molecular Pathogenesis [J].

Herrera, Guillermo A. .

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2014, 138 (10) :1365-1380

[3] Light chain deposition disease: novel biological insights and treatment advances [J].

Jimenez-Zepeda, V. H. .

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2012, 34 (04) :347-355

[4]

Kapur U, 2007, ARCH PATHOL LAB MED, V131, P1368

[5] Prevalence of monoclonal gammopathy of undetermined significance [J].

Kyle, RA ;

Therneau, TM ;

Rajkumar, SV ;

Larson, DR ;

Plevak, MF ;

Offord, JR ;

Dispenzieri, A ;

Katzmann, JA ;

Melton, LJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (13) :1362-1369

[6] The morphologic spectrum and clinical significance of light chain proximal tubulopathy with and without crystal formation [J].

Larsen, Christopher P. ;

Bell, Jane M. ;

Harris, Alexis A. ;

Messias, Nidia C. ;

Wang, Yihan H. ;

Walker, Patrick D. .

MODERN PATHOLOGY, 2011, 24 (11) :1462-1469

[7] Adult Fanconi syndrome secondary to light chain gammopathy - Clinicopathologic heterogeneity and unusual features in 11 patients [J].

Messiaen, T ;

Deret, S ;

Mougenot, B ;

Bridoux, F ;

Dequiedt, P ;

Dion, JJ ;

Makdassi, R ;

Meeus, F ;

Pourrat, J ;

Touchard, G ;

Vanhille, P ;

Zaoui, P ;

Aucouturier, P ;

Ronco, PM .

MEDICINE, 2000, 79 (03) :135-154

[8]

ROSENTHAL NS, 1994, HEMATOL PATHOL, V8, P43

[9] Light chain tubulopathy without Fanconi syndrome [J].

Said, Samar M. ;

Assaad, Adel M. ;

Cerda, Jorge ;

Nasr, Samih H. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (12) :3589-3590

[10]

Sharma SG, 2012, ISRN PATHOL, V2012

← 1 2 →