A CONVENIENT SYNTHESIS OF TRANS-3'-HYDROXYCOTININE, A MAJOR NICOTINE METABOLITE FOUND IN THE URINE OF TOBACCO USERS

被引：4

作者：

DESAI, D ^{[1
]}

AMIN, S ^{[1
]}

机构：

[1] AMER HLTH FDN,DIV CHEM CARCINOGENESIS,VALHALLA,NY 10595

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1990年 / 3卷 / 01期

关键词：

D O I：

10.1021/tx00013a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

trans-3’-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3’-hydroxycotinine from cotinine in two steps by using NaN[(CH3)3Si]2 and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis. © 1990, American Chemical Society. All rights reserved.

引用

页码：47 / 48

页数：2

共 9 条

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