Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association

被引：4

作者：

Mu, Yunxiang ^{[1
]}

McBride, Kevin M. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Epigenet & Mol Carcinogenesis, Sci Pk, Smithville, TX USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 05期

关键词：

AICDA; activation-induced cytidine deaminase; B cells; class switch recombination; chromosome translocation; lithium; lymphoma; mutation; MYC;

D O I：

10.1080/23723556.2018.1432259

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of "off-target" mutagenesis and identify a drug that increases this activity. These studies demonstrate how dysregulating AID phosphorylation can promote oncogenesis.

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页数：3

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