Neurocognitive Changes and Their Neural Correlates in Patients with Type 2 Diabetes Mellitus

被引：35

作者：

Lee, Junghyun H. ^{[1
,2
,3
]}

Choi, Yera ^{[3
,4
]}

Jun, Chansoo ^{[1
,2
,3
]}

Hong, Young Sun ^{[3
,5
]}

Cho, Han Byul ^{[3
,4
]}

Kim, Jieun E. ^{[3
,6
]}

Lyoo, In Kyoon ^{[1
,2
,3
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Seoul, South Korea

[2] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul, South Korea

[3] Ewha Womans Univ, Ewha Brain Inst, Seoul, South Korea

[4] Seoul Natl Univ, Coll Nat Sci, Interdisciplinary Program Neurosci, Seoul, South Korea

[5] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[6] Ewha Womans Univ, Grad Sch, Dept Brain & Cognit Sci, Seoul, South Korea

来源：

ENDOCRINOLOGY AND METABOLISM | 2014年 / 29卷 / 02期

关键词：

Diabetes mellitus; type; 2; Cognition disorders; Dementia; Hyperglycemia; Hypoglycemia; Magnetic resonance imaging; Magnetic resonance spectroscopy;

D O I：

10.3803/EnM.2014.29.2.112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition.

引用

页码：112 / 121

页数：10

共 96 条

[1] Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy [J].