HISTONE STRUCTURE - ASYMMETRIC DISTRIBUTION OF LYSINE RESIDUES IN LYSINE-RICH HISTONE

被引：79
作者：
BUSTIN, M
RALL, SC
STELLWAG.RH
COLE, RD
机构：
[1] Department of Biochemistry, University of California
来源：
SCIENCE | 1969年 / 163卷 / 3865期
关键词：
D O I：
10.1126/science.163.3865.391-a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Structural studies on a very lysine-rich histone show that the carboxyl-terminal half of the molecule is enriched in lysine (and proline), which suggests that it is a site for binding to DNA. The amino-terminal half, containing most of the acidic residues, resembles small, nonhistone proteins and so might have specificity for factors other than DNA.
引用
收藏
页码：391 / &
相关论文
共 9 条
[1]  
BONNER J, 1964, NUCLEOHISTONES ED, P46
[2]  
BUSTIN M, 1968, J BIOL CHEM, V243, P4500
[3]  
BUSTIN M, IN PRESS
[4]  
BUSTIN M, 1968, THESIS U CALIFORNIA
[5]  
Gray W.R., 1967, METHODS ENZYMOL, V11, P139, DOI [10.1016/S0076-6879(67)11014-8, DOI 10.1016/S0076-6879(67)11014-8]
[6]   STUDY OF THE PROTEINASE CONTENT AND THE CHROMATOGRAPHY OF THYMUS HISTONES [J].
PHILLIPS, DMP ;
JOHNS, EW .
BIOCHEMICAL JOURNAL, 1959, 72 :538-544
[7]  
PHILLIPS DMP, 1964, NUCLEOHISTONES, P46
[8]  
Ramachandran L.K., 1967, METHOD ENZYMOL, V11, P283
[9]   MOLECULAR WEIGHT OF LYSINE-RICH HISTONE [J].
TELLER, DC ;
KINKADE, JM ;
COLE, RD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1965, 20 (06) :739-+
1