ROTENOIDS AND CHALCONES FROM MUNDULEA-SERICEA THAT INHIBIT PHORBOL ESTER-INDUCED ORNITHINE DECARBOXYLASE ACTIVITY

被引：68

作者：

LUYENGI, L ^{[1
]}

LEE, IS ^{[1
]}

MAR, W ^{[1
]}

FONG, HHS ^{[1
]}

PEZZUTO, JM ^{[1
]}

KINGHORN, AD ^{[1
]}

机构：

[1] UNIV ILLINOIS, COLL PHARM, DEPT MED CHEM & PHARMACOGNOSY, PROGRAM COLLABORAT RES PHARMACEUT SCI, CHICAGO, IL 60612 USA

来源：

PHYTOCHEMISTRY | 1994年 / 36卷 / 06期

关键词：

MUNDULEA SERICEA; LEGUMINOSAE; BARK; ROTENOIDS; CHALCONE; ORNITHINE DECARBOXYLASE INHIBITORY ACTIVITY;

D O I：

10.1016/S0031-9422(00)89755-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two novel rotenoids, (-)-13 alpha-hydroxydeguelin and (-)-13 alpha-hydroxytephrosin, and a new chalcone, munsericin, were isolated from the bark of Mundulea sericea, and their structures were elucidated by spectroscopic methods. Also obtained were the parent rotenoids, deguelin and tephrosin, and the known chalcone, 4-hydroxylonchocarpin. The rotenoids and chalcones exhibited potent inhibitory activity against phorbol ester-induced ornithine decarboxylase activity in cultured mouse 308 epidermal cells.

引用

页码：1523 / 1526

页数：4

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