THE ROLE OF THE HUMAN GENOME PROJECT IN DISEASE PREVENTION

被引：10

作者：

GOTTESMAN, MM ^{[1
]}

COLLINS, FS ^{[1
]}

机构：

[1] NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892

来源：

PREVENTIVE MEDICINE | 1994年 / 23卷 / 05期

关键词：

D O I：

10.1006/pmed.1994.1094

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Human Genome Project has made it easier to genetically map and clone mutant genes which predispose to a great many human diseases. In addition to diseases inherited in a simple Mendelian fashion, there are many degenerative and infectious diseases, and sensitivities to environmental insults, in which the genetic make-up of an individual contributes to the course of the disease. Once a gene or genes associated with disease has been cloned, it is possible to design DNA-based diagnostics to detect altered forms of the gene which predispose to disease. The ability to predict the development of disease makes possible early intervention to limit the severity of a disease or to use gene therapy to cure inherited disorders.

引用

页码：591 / 594

页数：4