ELECTROCHEMICAL STUDY OF AMIODARONE CHARGE-TRANSFER COMPLEXES

The electron-donating properties of the drug amiodarone (also known as cordarone), have been studied by conductimetry. Amiodarone was found to form a charge-transfer complex in vitro with the electron acceptor iodine, which is involved in human thyroid metabolism. Amiodarone was also found to interact with some other biological molecules with the capacity to behave as electron acceptors, such as dopamine hydrochloride, (-)epinephrine, serotonin hydrochloride, coenzyme Q(o), and beta-nicotinamide adenine dinucleotide. An electronic absorption band in the visible region of the spectrum due to charge-transfer complex formation between iodine and amiodarone was also observed, supporting the conductimetric results.