MOLECULAR-BASIS OF THE EFFICACY OF CEFACLOR AGAINST HAEMOPHILUS-INFLUENZAE

被引：4
作者：
PICARD, M
MALOUIN, F
机构：
[1] CHU LAVAL,CTR RECH,DEPT MICROBIOL,QUEBEC CITY G1V 4G2,QUEBEC,CANADA
[2] CHU LAVAL,CTR RECH,SERV INFECTIOL,QUEBEC CITY G1V 4G2,QUEBEC,CANADA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 11期
关键词：
D O I：
10.1128/AAC.36.11.2569
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cefaclor sustained its inhibitory activity against a beta-lactamase-producing strain of Haemophilus influenzae. Although a relatively high permeability coefficient was calculated for ampicillin compared with that calculated for cefaclor, the resulting periplasmic concentration of cefaclor was 5.7 times that of ampicillin. The efficacy of cefaclor may be due to its higher beta-lactamase resistance, which allows it to achieve a greater periplasmic concentration and adequate binding to crucial penicillin-binding proteins.
引用
收藏
页码：2569 / 2572
页数：4
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