COMPARISON OF SISTER-CHROMATID EXCHANGE INDUCTION IN MURINE GERMINAL AND SOMATIC-CELLS BY GAMMA-RADIATION EXPOSURE IN-VIVO

被引:9
作者
MORALESRAMIREZ, P
MENDIOLACRUZ, MT
VALLARINOKELLY, T
RODRIGUEZREYES, R
机构
[1] Institute Nacional de Investigaciones Nucleares, México, Lomas Barrilaco
关键词
SCE; GAMMA RAY; SPERMATOGONIA; BONE MARROW CELL; SALIVARY GLAND CELL;
D O I
10.1002/em.2850240203
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Sister chromatid exchange (SCE) induction by gamma rays was determined in spermatogonia irradiated before or after BrdU incorporation. Furthermore, the comparison of responses obtained in spermatogonia, bone marrow and salivary gland cells was carried out in the cells irradiated after BrdU incorporation, a condition which permits a higher SCE induction. Results indicate that gamma ray exposure of spermatogonia could induce a significant increase in SCE frequency with doses as low as 0.27 Gy, either before or after BrdU incorporation. However, the increase caused by radiation exposure after BrdU incorporation in spermatogonia was nearly three times lower than that obtained in both bone marrow and salivary gland cells. These data suggest that spermatogonia are either more efficient in repairing the gamma ray-induced lesions involved in SCE production or that these cells are less prone to the induction of such lesions. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码:89 / 95
页数:7
相关论文
共 53 条
[1]   SISTER-CHROMATID EXCHANGE INDUCED BY X-RAY OF HUMAN LYMPHOCYTES AND EFFECT OF L-CYSTEINE [J].
ABRAMOVSKY, I ;
VORSANGER, G ;
HIRSCHHORN, K .
MUTATION RESEARCH, 1978, 50 (01) :93-100
[2]   ANALYSIS OF SISTER CHROMATID EXCHANGE FORMATION INVIVO IN MOUSE SPERMATOGONIA AS A NEW TEST SYSTEM FOR ENVIRONMENTAL MUTAGENS [J].
ALLEN, JW ;
LATT, SA .
NATURE, 1976, 260 (5550) :449-451
[3]   BROMODEOXYURIDINE TABLET METHODOLOGY FOR INVIVO STUDIES OF DNA-SYNTHESIS [J].
ALLEN, JW ;
SHULER, CF ;
LATT, SA .
SOMATIC CELL GENETICS, 1978, 4 (04) :393-405
[4]  
ANDERSSON HC, 1981, HEREDITAS, V94, P41
[5]   INDUCED CELL PROLIFERATION - EFFECT OF ISOPROTERENOL [J].
BARKA, T .
EXPERIMENTAL CELL RESEARCH, 1965, 37 (03) :662-&
[6]  
BASERGA R, 1970, FED PROC, V29, P1443
[7]   DNA-REPAIR IN AN ACTIVE GENE - REMOVAL OF PYRIMIDINE DIMERS FROM THE DHFR GENE OF CHO CELLS IS MUCH MORE EFFICIENT THAN IN THE GENOME OVERALL [J].
BOHR, VA ;
SMITH, CA ;
OKUMOTO, DS ;
HANAWALT, PC .
CELL, 1985, 40 (02) :359-369
[8]   ANALYSIS OF FREQUENCY OF SISTER CHROMATID EXCHANGE IN DIFFERENT REGIONS OF CHROMOSOMES OF KANGAROO RAT (DIPODOMYS-ORDII) [J].
BOSTOCK, CJ ;
CHRISTIE, S .
CHROMOSOMA, 1976, 56 (03) :275-287
[9]   DNA CROSSLINKING, SISTER-CHROMATID EXCHANGE AND SPECIFIC-LOCUS MUTATIONS [J].
CARRANO, AV ;
THOMPSON, LH ;
STETKA, DG ;
MINKLER, JL ;
MAZRIMAS, JA ;
FONG, S .
MUTATION RESEARCH, 1979, 63 (01) :175-188
[10]   DISTRIBUTION OF SISTER CHROMATID EXCHANGES IN EUCHROMATIN AND HETEROCHROMATIN OF INDIAN MUNTJAC [J].
CARRANO, AV ;
WOLFF, S .
CHROMOSOMA, 1975, 53 (04) :361-369