EFFECT OF ACUTE ZINC-DEFICIENCY ON INSULIN-RECEPTOR BINDING IN RAT ADIPOCYTES

被引：13

作者：

GOMOT, MJ

FAURE, P

ROUSSEL, AM

COUDRAY, C

OSMAN, M

FAVIER, A

机构：

[1] UFR PHARM,BIOCHIM LAB C,F-38700 LA TRONCHE,FRANCE

[2] HOP A MICHALLON,BIOCHIM LAB C,F-38043 GRENOBLE,FRANCE

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1992年 / 32卷

关键词：

INSULIN RESISTANCE; ZINC DEFICIENCY; RAT ADIPOCYTES; INSULIN BINDING;

D O I：

10.1007/BF02784619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Considerable data have been reported on the relationship between insulin resistance and zinc deficiency. In this study, insulin receptor binding was measured in isolated rat adipocytes. Two assays were carried out at 37-degrees-C (binding and internalization) and 16-degrees-C (binding) using I-125 insulin 0.05-20 nM. A decreased insulin receptor binding was observed in zinc-deficient rat adipocytes, but we could not make any distinction between the specific zinc depletion effects and the effects of the caloric restriction induced by zinc deficiency.

引用

页码：331 / 335

页数：5

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