CONTROL OF STAPHYLOCOCCAL ADHESION TO POLYSTYRENE SURFACES BY POLYMER SURFACE MODIFICATION WITH SURFACTANTS

被引：110
|
作者：
BRIDGETT, MJ
DAVIES, MC
DENYER, SP
机构：
[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,UNIV PK,NOTTINGHAM NG7 2RD,ENGLAND
[2] BRIGHTON POLYTECH,SCH PHARM,BRIGHTON BN2 4GJ,E SUSSEX,ENGLAND
来源：
BIOMATERIALS | 1992年 / 13卷 / 07期
关键词：
BACTERIAL ADHESION; SURFACTANTS; SURFACE MODIFICATION;
D O I：
10.1016/0142-9612(92)90159-L
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The adherence of three clinical isolates of Staphylococcus epidermidis to model polystyrene surfaces was studied in vitro using epifluorescent image analysis. A series of 16 Pluronic surfactants (A-B-A block copolymers where A is poly(ethylene oxide) (PEO) and B is poly(propylene oxide) (PPO)) were used as surface modifiers for the model polystyrene surfaces. Substantial reductions (up to 97%) in bacterial adhesion levels were achieved with all copolymers tested, irrespective of the PPO or PEO block lengths. It appears likely that such treatments create a sterically stabilized surface with adsorbed PEO chains, conferring non-specific anti-adhesive properties which can limit bacterial attachment.
引用
收藏
页码：411 / 416
页数：6
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