ANALYSIS BY MESSENGER-RNA LEVELS OF THE EXPRESSION OF 6 G-PROTEIN ALPHA-SUBUNIT GENES IN MAMMALIAN-CELLS AND TISSUES

被引：50
|
作者：
GARIBAY, JLR [1 ]
KOZASA, T [1 ]
ITOH, H [1 ]
TSUKAMOTO, T [1 ]
MATSUOKA, M [1 ]
KAZIRO, Y [1 ]
机构：
[1] UNIV TOKYO,INST MED SCI,MINATO KU,TOKYO 113,JAPAN
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1094卷 / 02期
关键词：
G-PROTEIN; ALPHA-SUBUNIT; SIGNAL TRANSDUCTION; EXPRESSION; DEVELOPMENT; (MAMMALIAN CELL AND TISSUE);
D O I：
10.1016/0167-4889(91)90008-L
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The distribution and levels of expression of Gs-alpha, Gil-alpha, Gi2-alpha, Gi3-alpha, Go-alpha, and Gx-alpha mRNAs were compared by Northern blot analysis using several rat tissues and selected human and rat cell lines. Gi1-alpha, Go-alpha, and Gx-alpha, were detected in a limited number of tissue and cells whereas Gi2-alpha, Gi3-alpha, and Gs-alpha, were expressed in all the tissues and cells tested albeit in varying amounts. The expression of these six genes appears to be differentially regulated during postnatal development of the rat brain. High expression levels particularly of Go-alpha, in young rat brain may be related to the formation of neurites during differentiation of nerve cells.
引用
收藏
页码：193 / 199
页数：7
相关论文
共 50 条
  • [21] EXPRESSION IN ESCHERICHIA-COLI OF THE ALPHA-SUBUNIT OF THE G-PROTEIN, TRANSDUCIN
    FORD, J
    HIGGINS, CF
    WATTS, A
    PROTEIN ENGINEERING, 1993, 6 : 77 - 77
  • [22] BACULOVIRUS EXPRESSION AND PURIFICATION OF A SOLUBLE, MUTANT G-PROTEIN ALPHA-SUBUNIT
    JONES, TLZ
    WOODARD, C
    SPIEGEL, AM
    PROTEIN EXPRESSION AND PURIFICATION, 1993, 4 (01) : 64 - 71
  • [23] HISTONE MESSENGER-RNA EXPRESSION IN G1-ARRESTED AND G1-CYCLING MAMMALIAN-CELLS
    BIEBER, D
    GROPPI, V
    CHIU, I
    SITTMAN, D
    COFFINO, P
    MARZLUFF, W
    JOURNAL OF CELL BIOLOGY, 1981, 91 (02): : A12 - A12
  • [24] GLUCOCORTICOID-ALTERED G-PROTEIN ALPHA-SUBUNIT EXPRESSION IN JURKAT LYMPHOMA-CELLS
    LAZAREVIC, MB
    RASENICK, MM
    SWEDLER, WI
    LIU, S
    BIFERO, T
    SKOSEY, JL
    CLINICAL RESEARCH, 1994, 42 (02): : A311 - A311
  • [25] KINETICS OF EXPRESSION OF ACH RECEPTOR ALPHA-SUBUNIT MESSENGER-RNA IN DENERVATED AND STIMULATED MUSCLE
    NEVILLE, C
    SCHMIDT, M
    SCHMIDT, J
    NEUROREPORT, 1991, 2 (11) : 655 - 657
  • [26] CHRONIC HALOPERIDOL DOES NOT ALTER G-PROTEIN ALPHA-SUBUNIT LEVELS IN RATS
    SEE, RE
    STRIPLIN, C
    KALIVAS, PW
    MOLECULAR BRAIN RESEARCH, 1993, 19 (03): : 219 - 221
  • [27] THYROID-HORMONES REGULATE G-PROTEIN BETA-SUBUNIT MESSENGER-RNA EXPRESSION INVIVO
    RAPIEJKO, PJ
    WATKINS, DC
    ROS, M
    MALBON, CC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (27) : 16183 - 16189
  • [28] ALTERED EXPRESSION OF G-PROTEIN MESSENGER-RNA IN SPONTANEOUSLY HYPERTENSIVE RATS
    THIBAULT, C
    ANANDSRIVASTAVA, MB
    FEBS LETTERS, 1992, 313 (02) : 160 - 164
  • [29] EXPRESSION OF NA-K-ATPASE ALPHA-SUBUNIT AND BETA-SUBUNIT MESSENGER-RNA AND PROTEIN ISOFORMS IN THE RAT NEPHRON
    TUMLIN, JA
    HOBAN, CA
    MEDFORD, RM
    SANDS, JM
    AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (02): : F240 - F245
  • [30] MESSENGER-RNA OF G-PROTEINS ALPHA-SUBUNIT IN RAT BROWN ADIPOSE-TISSUE
    DEPERGOLA, G
    XU, X
    CARLSSON, B
    ERIKSSON, P
    GIORGINO, R
    BJORNTORP, P
    INTERNATIONAL JOURNAL OF OBESITY, 1994, 18 (04) : 269 - 272
12345