ANALYSIS BY MESSENGER-RNA LEVELS OF THE EXPRESSION OF 6 G-PROTEIN ALPHA-SUBUNIT GENES IN MAMMALIAN-CELLS AND TISSUES

被引：50

作者：

GARIBAY, JLR ^{[1
]}

KOZASA, T ^{[1
]}

ITOH, H ^{[1
]}

TSUKAMOTO, T ^{[1
]}

MATSUOKA, M ^{[1
]}

KAZIRO, Y ^{[1
]}

机构：

[1] UNIV TOKYO,INST MED SCI,MINATO KU,TOKYO 113,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1094卷 / 02期

关键词：

G-PROTEIN; ALPHA-SUBUNIT; SIGNAL TRANSDUCTION; EXPRESSION; DEVELOPMENT; (MAMMALIAN CELL AND TISSUE);

D O I：

10.1016/0167-4889(91)90008-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The distribution and levels of expression of Gs-alpha, Gil-alpha, Gi2-alpha, Gi3-alpha, Go-alpha, and Gx-alpha mRNAs were compared by Northern blot analysis using several rat tissues and selected human and rat cell lines. Gi1-alpha, Go-alpha, and Gx-alpha, were detected in a limited number of tissue and cells whereas Gi2-alpha, Gi3-alpha, and Gs-alpha, were expressed in all the tissues and cells tested albeit in varying amounts. The expression of these six genes appears to be differentially regulated during postnatal development of the rat brain. High expression levels particularly of Go-alpha, in young rat brain may be related to the formation of neurites during differentiation of nerve cells.

引用

页码：193 / 199

页数：7

共 46 条

[1] GO, A GTP-BINDING PROTEIN - IMMUNOCHEMICAL AND IMMUNOHISTOCHEMICAL LOCALIZATION IN THE RAT [J].