Association of MTHFR and TNF-alpha genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study

被引：15

作者：

Azarpira, Mohammad Reza ^{[1
]}

Ghilian, Mohammad Mahdi ^{[1
]}

Sobhan, Mohammad Reza ^{[2
]}

Mehdinezhad-Yazdi, Masoud ^{[2
]}

Aghili, Kazem ^{[3
]}

Miresmaeili, Seyed Mohsen ^{[4
]}

Neamatzadeh, Hossein ^{[5
]}

机构：

[1] Shiraz Univ Med Sci, Bone & Joint Dis Res Ctr, Shiraz, Iran

[2] Shahid Sadoughi Univ Med Sci, Dept Orthoped, Yazd, Iran

[3] Shahid Sadoughi Univ Med Sci, Dept Radiol, Yazd, Iran

[4] Sci & Art Univ, Dept Biol, Yazd, Iran

[5] Shahid Sadoughi Univ Med Sci, Dept Med Genet, Yazd, Iran

来源：

JOURNAL OF ORTHOPAEDICS | 2018年 / 15卷 / 04期

关键词：

Legg-Calve-Perthes' disease; MTHFR; TNF-alpha; Polymorphism;

D O I：

10.1016/j.jor.2018.08.042

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: The aim of this study was to assess the association of MTHFR and TNF-alpha genes polymorphisms with Legg-Calve-Perthes' disease (LCPD) risk in the Iranian children. Methods: A total of 45 children with LCPD and 55 healthy controls were recruited to the study. Genotyping was performed via the RFLP-PCR method and genetic risk was calculated by odds ratio (OR) with its corresponding 95% confidence interval (CI). Results & conclusion: Our case-control study failed to determine any association of MTHFR (677C > T and 1298A > C) and TNF-alpha ( - 308G > A and - 238G > A) polymorphisms with LCPD risk. More studies with larger sample size are warranted to validate our findings.

引用

页码：984 / 987

页数：4

共 20 条

[1]

Abedinzadeh Mehdi, 2015, Asian Pac J Cancer Prev, V16, P4525

[2] Legg-Calve-Perthes disease in two generations of male family members: a case report [J].

Al-Omran, Ammar K. ;

Sadat-Ali, Mir .

JOURNAL OF ORTHOPAEDIC SURGERY, 2013, 21 (02) :258-261

[3] Apoptosis - a significant cause of bone cell death in osteonecrosis of the femoral head [J].

Calder, JDF ;

Buttery, L ;

Revell, PA ;

Pearse, M ;

Polak, JM .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2004, 86B (08) :1209-1213

[4] Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head [J].

Chai, Wei ;

Zhang, Zhendong ;

Ni, Ming ;

Geng, Peiliang ;

Lian, Zijian ;

Zhang, Guoqiang ;

Shi, Lewis L. ;

Chen, Jiying .

BIOMED RESEARCH INTERNATIONAL, 2015, 2015

[5]

Glueck CJ, 2001, CLIN ORTHOP RELAT R, P19

[6]

Kamali Mahdieh, 2018, Iranian Biomedical Journal, V22, P78, DOI 10.22034/ibj.22.2.78

[7] Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population [J].

Kim, Tae-Ho ;

Hong, Jung Min ;

Kim, Hyun-Ju ;

Park, Eui Kyun ;

Kim, Shin-Yoon .

MOLECULES AND CELLS, 2010, 29 (04) :343-348

[8] Legg-Calve-Perthes disease [J].

Leroux, J. ;

Abu Amara, S. ;

Lechevallier, J. .

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH, 2018, 104 (01) :S107-S112

[9] A Novel p. Gly630Ser Mutation of COL2A1 in a Chinese Family with Presentations of Legg-Calve-Perthes Disease or Avascular Necrosis of the Femoral Head [J].

Li, Na ;

Yu, Jian ;

Cao, Xiang ;

Wu, Qiu-Yue ;

Li, Wei-Wei ;

Li, Tian-Fu ;

Zhang, Cui ;

Cui, Ying-Xia ;

Li, Xiao-Jun ;

Yin, Zhi-Min ;

Xia, Xin-Yi .

PLOS ONE, 2014, 9 (06)

[10]

Loder Randall T, 2011, ISRN Orthop, V2011, P238607, DOI 10.5402/2011/238607

← 1 2 →