2 ENANTIOSELECTIVE SYNTHESES OF A PRECURSOR OF THE BIOLOGICALLY MOST ACTIVE ISOMER OF CGA 80000 (CLOZYLACON)

被引：36

作者：

BUSER, HP ^{[1
]}

PUGIN, B ^{[1
]}

SPINDLER, F ^{[1
]}

SUTTER, M ^{[1
]}

机构：

[1] CIBA GEIGY AG,CENT RES LABS,CH-4002 BASEL,SWITZERLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 30期

关键词：

D O I：

10.1016/S0040-4020(01)86523-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The unchlorinated precursor 4 of CGA 80000 (1) was synthesized enantioselectively by two conceptionally different routes: a) by a ''chiral pool'' approach starting from L-malic acid and b) by enantioselective hydrogenation of an enamide intermediate, catalyzed by chiral Rh- or Ru-phosphine-complexes.

引用

页码：5709 / 5716

页数：8

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