SEVERE POSTHEMICOLECTOMY DIARRHEA - EVALUATION AND TREATMENT WITH SMS-201-995

被引:11
|
作者
SHARKEY, MF
KADDEN, ML
STABILE, BE
机构
[1] VET ADM MED CTR,DEPT MED,SAN DIEGO,CA 92161
[2] VET ADM MED CTR,DEPT SURG,SAN DIEGO,CA 92161
关键词
D O I
10.1016/0016-5085(90)90637-G
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The effect of subcutaneous somatostatin analogue SMS 201-995 (Sandoz Pharmaceuticals Corp., East Hanover, NJ) was investigated in a patient with acute postoperative secretory diarrhea. The patient was hospitalized with bowel obstruction caused by a descending colon adenocarcinoma. One week after left hemicolectomy and transverse colostomy, watery colostomy output, which exceeded 10 L per day developed. Jejunal perfusion studies suggested that the patient's diarrhea was caused by abnormal net secretion of water and electrolytes by the small intestine. Circulating levels of various peptide hormones were normal with the exception of elevated level of pancreatic polypeptide. SMS 201-995 administration reduced colostomy output and normalized many of the abnormalities found during jejunal perfusion. These results indicate that the patient's acute secretory diarrhea, occurring after large intestinal obstruction, originated in the small intestine and that SMS 201-995 can be used to manage this unusual severe postoperative problem. © 1990.
引用
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页码:1144 / 1148
页数:5
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