MUTATION AND INACTIVATION OF CULTURED MAMMALIAN-CELLS EXPOSED TO BEAMS OF ACCELERATED HEAVY-IONS .3. HUMAN-DIPLOID FIBROBLASTS

被引:113
作者
COX, R
MASSON, WK
机构
[1] Medical Research Council, Radiobiology Unit, Harwell, Didcot, Oxon, OX11 0RD, England
基金
英国医学研究理事会;
关键词
D O I
10.1080/09553007914550901
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The induction of inactivation and mutation to thioguanine-resistance in cultured human diploid fibroblasts was studied after exposure to ionising radiations with LETs in the range 20-470keV μm-1. Unique r.b.e. values were obtained for inactivation and mutation induction with nine different qualities of radiation. The plot of r.b.e. versus LET gave humped curves for both endpoints; r.b.e. maxima were in the LET range 90-200keV μm-1 but the maximum r.b.e. value for mutation induction was almost twice that for inactivation. The accuracy of estimates of mutation induction are discussed with regard to possible selective effects against mutants during post-irradiation growth. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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收藏
页码:149 / 160
页数:12
相关论文
共 21 条
[1]  
Barendsen G.W., 1968, CURR TOP RADIAT RES, V4, P293
[2]   EFFECTS OF DIFFERENT IONIZING RADIATIONS ON HUMAN CELLS IN TISSUE CULTURE .3. EXPERIMENTS WITH CYCLOTRON-ACCELERATED ALPHA-PARTICLES AND DEUTERONS [J].
BARENDSEN, GW ;
WALTER, HMD ;
BEWLEY, DK ;
FOWLER, JF .
RADIATION RESEARCH, 1963, 18 (01) :106-&
[3]   IMPAIRMENT OF THE PROLIFERATIVE CAPACITY OF HUMAN CELLS IN CULTURE BY ALPHA-PARTICLES WITH DIFFERING LINEAR-ENERGY TRANSFER [J].
BARENDSEN, GW .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1964, 8 (05) :453-466
[4]   SURVIVAL OF SYNCHRONIZED CHINESE-HAMSTER CELLS EXPOSED TO RADIATION OF DIFFERENT LINEAR ENERGY TRANSFER [J].
BIRD, RP ;
BURKI, HJ .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1975, 27 (02) :105-120
[5]   REPORT OF COMMITTEE ON GENETIC CONSTITUTION OF X AND Y CHROMOSOMES [J].
BROWN, JA ;
GOSS, S ;
KLINGER, HP ;
MILLER, OJ ;
OHNO, S ;
SINISCALCO, M .
CYTOGENETICS AND CELL GENETICS, 1976, 16 (1-5) :54-59
[6]   CHANGES IN RADIOSENSITIVITY DURING INVITRO GROWTH OF DIPLOID HUMAN FIBROBLASTS [J].
COX, R ;
MASSON, WK .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1974, 26 (02) :193-196
[7]   INACTIVATION AND MUTATION OF CULTURED MAMMALIAN-CELLS BY ALUMINUM CHARACTERISTIC ULTRASOFT X-RAYS .2. DOSE-RESPONSES OF CHINESE-HAMSTER AND HUMAN DIPLOID CELLS TO ALUMINUM X-RAYS AND RADIATIONS OF DIFFERENT LET [J].
COX, R ;
THACKER, J ;
GOODHEAD, DT .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1977, 31 (06) :561-576
[8]   MUTATION AND INACTIVATION OF MAMMALIAN-CELLS BY VARIOUS IONIZING-RADIATIONS [J].
COX, R ;
THACKER, J ;
GOODHEAD, DT ;
MUNSON, RJ .
NATURE, 1977, 267 (5610) :425-427
[9]   X-RAY-INDUCED MUTATION TO 6-THIOGUANINE RESISTANCE IN CULTURED HUMAN DIPLOID FIBROBLASTS [J].
COX, R ;
MASSON, WK .
MUTATION RESEARCH, 1976, 37 (01) :125-136
[10]   ALTERNATIVE TO PETRI DISHES IN QUANTITATIVE MUTATION EXPERIMENTS WITH CULTURED MAMMALIAN-CELLS [J].
COX, R ;
MASSON, WK ;
BANCE, DA .
MUTATION RESEARCH, 1976, 35 (01) :173-177