LOW ACTIVITY OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN SERUM OF ACUTE INTRAHEPATIC CHOLESTASIS

被引：2
|
作者：
KAJIWARA, E
AKAGI, K
TSUJI, H
MURAI, K
FUJISHIMA, M
机构：
来源：
ENZYME | 1991年 / 45卷 / 1-2期
关键词：
GAMMA-GLUTAMYL TRANSPEPTIDASE; ALKALINE PHOSPHATASE; ACUTE INTRAHEPATIC CHOLESTASIS; CHOLESTATIC HEPATITIS; FULMINANT HEPATITIS;
D O I：
10.1159/000468863
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Low gamma-glutamyl transpeptidase (gamma-GTP) activity in serum was observed in 11 patients with acute intrahepatic cholestasis (cholestatic hepatitis and fulminant hepatitis), despite a marked increase in bilirubin levels. Inhibitors of gamma-GTP were not detected in sera of these patients. Their gamma-GTP levels in the liver were significantly higher than those in chronic liver diseases. An electrophoretic study of liver gamma-GTP in acute intrahepatic cholestasis showed the same mobility as in chronic liver diseases. These results suggest that the low serum gamma-GTP activity in acute intrahepatic cholestasis is due to factors inhibiting the release of the enzyme from the liver.
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页码：39 / 46
页数：8
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