CORTICAL SENILE PLAQUES IN CORONARY-ARTERY DISEASE, AGING AND ALZHEIMERS-DISEASE

被引：257
|
作者：
SPARKS, DL
HUNSAKER, JC
SCHEFF, SW
KRYSCIO, RJ
HENSON, JL
MARKESBERY, WR
机构：
[1] UNIV KENTUCKY,MED CTR,SANDERS BROWN CTR AGING,DEPT NEUROL,LEXINGTON,KY 40536
[2] UNIV KENTUCKY,MED CTR,SANDERS BROWN CTR AGING,DEPT ANAT & NEUROBIOL,LEXINGTON,KY 40536
[3] UNIV KENTUCKY,MED CTR,SANDERS BROWN CTR AGING,DEPT STAT,LEXINGTON,KY 40536
[4] KENTUCKY JUSTICE CABINET,MED EXAMINERS PROGRAM,LEXINGTON,KY 40536
来源：
NEUROBIOLOGY OF AGING | 1990年 / 11卷 / 06期
关键词：
Alzheimer's disease; Coronary artery disease; Heart disease; Neuropathology of the Alzheimer's type; Senile plaques;
D O I：
10.1016/0197-4580(90)90024-T
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Mild alterations in cognitive function are present in normal aging and severe cognitive alterations are a hallmark of Alzheimer's disease (AD). The cognitive change in AD has been correlated to the characteristic pathologic lesions in the brain, senile plaques (SP) and neurofibrillary tangles. Senile plaques are the most consistent correlative marker in AD. We present preliminary data indicating that abundant SP are found in the brains of nondemented patients dying with or as a result of critical coronary artery disease (cCAD) compared to nonheart disease (non-HD) subjects; 15 of 20 cCAD patients contained SP and only two of 16 non-HD patients contained SP. © 1990.
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页码：601 / 607
页数：7
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