STRUCTURE OF THE HUMAN G-GAMMA-A-GAMMA-DELTA-BETA-GLOBIN GENE LOCUS

被引：63

作者：

BERNARDS, R ^{[1
]}

LITTLE, PFR ^{[1
]}

ANNISON, G ^{[1
]}

WILLIAMSON, R ^{[1
]}

FLAVELL, RA ^{[1
]}

机构：

[1] UNIV LONDON,ST MARYS HOSP MED SCH,DEPT BIOCHEM,LONDON W2 1PG,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 10期

关键词：

D O I：

10.1073/pnas.76.10.4827

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have constructed a physical map of the human Gγ-, Aγ-,δ-, and β-globin genes. The previously described maps of the fetal and adult β-like globin genes have been linked to one another by identification of a DNA fragment, generated by bamHI, that contains part of each of the Aγ- and δ-globin genes. The map obtained, which spans more than 40 kilobases, shows the following intergene distances: between Gγ and Aγ, 3500 base pairs; between Aγ and δ, 13,500 base pairs; and between δ and β, 5500 base pairs. All genes are transcribed from the same DNA strand.

引用

页码：4827 / 4831

页数：5

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