ASSOCIATION OF FLAVIN ADENINE-DINUCLEOTIDE WITH THE ARABIDOPSIS BLUE-LIGHT RECEPTOR CRY1

被引：366
|
作者：
LIN, CT
ROBERTSON, DE
AHMAD, M
RAIBEKAS, AA
JORNS, MS
DUTTON, PL
CASHMORE, AR
机构：
[1] UNIV PENN, INST PLANT SCI, DEPT BIOL, PHILADELPHIA, PA 19104 USA
[2] UNIV PENN, SCH MED, JOHNSON FDN, DEPT BIOCHEM & BIOPHYS, PHILADELPHIA, PA 19104 USA
[3] HAHNEMANN UNIV, SCH MED, DEPT BIOL CHEM, PHILADELPHIA, PA 19102 USA
来源：
SCIENCE | 1995年 / 269卷 / 5226期
关键词：
D O I：
10.1126/science.7638620
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Arabidopsis thaliana HY4 gene encodes CRY1, a 75-kilodalton flavoprotein mediating blue light-dependent regulation of seedling development. CRY1 is demonstrated here to noncovalently bind stoichiometric amounts of flavin adenine dinucleotide (FAD). The redox properties of FAD bound by CRY1 include an unexpected stability of the neutral radical flavosemiquinone (FADH .). The absorption properties of this flavosemiquinone provide a likely explanation for the additional sensitivity exhibited by CRY1-mediated responses in the green region of the visible spectrum, Despite the sequence homology to microbial DNA photolyases, CRY1 was found to have no detectable photolyase activity.
引用
收藏
页码：968 / 970
页数：3
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