LOW-MOLECULAR-WEIGHT END-FUNCTIONALIZED POLY(N-VINYLPYRROLIDINONE) FOR THE MODIFICATION OF POLYPEPTIDE AMINOGROUPS

被引：28

作者：

SARTORE, L ^{[1
]}

RANUCCI, E ^{[1
]}

FERRUTI, P ^{[1
]}

CALICETI, P ^{[1
]}

SCHIAVON, O ^{[1
]}

VERONESE, FM ^{[1
]}

机构：

[1] UNIV PADUA,CNR,CTR CHIM FARMACO,DIPARTIMENTO SCI FARMACEUT,I-35131 PADUA,ITALY

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 1994年 / 9卷 / 04期

关键词：

D O I：

10.1177/088391159400900404

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New monofunctionalized amphiphilic oligomers, poly (N-vinyl pyrrolidinones) with an hydroxyl end group, were prepared by radical polymerization with 2-isopropoxyethanol, fractionated by both gel-permeation chromatography and fractional precipitation. The terminal hydroxyl group oligomers was activated and reacted with the amino groups of a model peptide, and a protein. These hydroxylated oligomers were also converted to carboxylate end group which were also activated and used as protein and peptide modifying agents.

引用

页码：411 / 428

页数：18

共 28 条

[1]

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[2]

BOCCU E, Z NATUR FORSCH, V38, P94

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